The Youghiogheny River provides good wilderness trout fishing.
In cooperation with the Pennsylvania Fish and Boat Commission, fingerling trout are stocked throughout the entire section of river within the park.
An all-tackle trophy trout program exists on a nine-mile section of the river from Ramcat downstream to the PA 381 bridge in Ohiopyle.
Meadow Run also provides fine trout fishing for anglers who prefer smaller stream fishing.
A 2.2-mile section of Meadow Run, from Dinnerbell Road downstream to the mouth of the river, is designated for delayed harvest, artificial lures only.
Pennsylvania Fish and Boat Commission laws apply. Complete information about fishing rules and regulations in Pennsylvania is available from the Pennsylvania Fish and Boat Commission.